Modular Stereocontrolled Assembly of R2Zn, Cyclic Enones and N-tert-Butanesulfinyl Imines

The assembly of a wide range of dialkylzincs, cyclic enones, and chiral N-tert-butylsulfinyl imines in the presence of the appropriate phosphoramidite ligands allowed the formation of beta-amino ketones with three consecutive stereogenic centers in a stereocontrolled manner. The Baeyer-Villiger oxidation of the resulting amino ketones led to the corresponding aminolactones with excellent regio- and stereoselectivities.