Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 14, Pages 5340-5353Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo800615d
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- ICREA Funding Source: Custom
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The structural optimization of a family of modular, enantiopure beta-amino alcohol ligands with a common 2-amino-2-aryl-1,1-diphenylethanol skeleton, whose stereogenicity was introduced through the Jacobsen epoxidation of 1,1-diphenyl-2-arylethylenes, has led to the identification of a small set of optimal catalysts with enhanced activity and enantioselectivity in the addition of alkylzinc and arylzinc reagents to aldehydes. Criteria for the discrimination between apparently analogous, highly enantioselective ligands are proposed.
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