Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 10, Pages 3964-3966Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8003293
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Funding
- NIGMS NIH HHS [R21 GM 078447] Funding Source: Medline
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Fluorogenic imines and their precursor amines that can be used for fluorescent visualization of Mannich-type reactions of phenols in aqueous buffers have been developed. The precursor amines are aniline derivatives that are covalently conjugated to fluorophores. These amines and their imine derivatives were nonfluorescent or very weakly fluorescent. On the other hand, addition products of the imines to phenols showed more than 100-fold higher fluorescence than the imines and the precursor amines.
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