Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 21, Pages 8669-8672Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8017389
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Funding
- NIH [R21 GM078447]
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Cyclic imine derivatives that react with phenols, including tyrosine residues of peptides, have been developed. Reactions of the imines with phenols proceeded in water over a wide pH range (pH 2-10) at room temperature to 37 degrees C and afforded Mannich products without the need of additional catalysts.
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