4.7 Article

Controllable one-step synthesis of spirocycles, polycycles, and di- and tetrahydronaphthalenes from aryl-substituted propargylic alcohols

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 17, Pages 6845-6848

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo801210n

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Funding

  1. NNSF of China
  2. NSF of Shanghai
  3. Shanghai Leading Academic Discipline Project [13108]

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A novel, convenient, and efficient method has been developed for selective synthesis of spirocycle, polycycle, and di- and tetrahydronaphthalene systems from aryl-substituted propargylic alcohols by FeCl(3)- or TsOH-catalyzed multiple activations of unsaturated C-C bonds and C-H bonds.

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