Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 11, Pages 3975-3984Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo800239a
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Funding
- FIC NIH HHS [U01 TW000313, U01 TW000313-14, U01 TW000313-13, U01 TW000313-15, U01 TW 00313] Funding Source: Medline
- NCI NIH HHS [R01 CA 69571, R01 CA069571-12, R01 CA069571-11, R01 CA069571-13, R01 CA069571] Funding Source: Medline
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Recent research oil the chemistry of natural products from the author's group that led to the receipt of the ACS Ernest Guenther Award in the Chemistry of Natural Products is reviewed. REDOR NMR and synthetic studies established the T-taxol conformation as the bioactive tubulin-binding conformation, mid these results were confirmed by the synthesis of compounds which clearly owed their activity or lack of activity to whether or not they could adopt the T-taxol conformation. Similar studies with the epothilones suggest that the current tubulin-bindin,, model needs to be modified. Examples of natural products discovery and biodiversity conservation in Suriname and Madagascar Lire also presented, and it is concluded that natural products chemistry will continue to make significant contributions to drug discovery.
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