Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 22, Pages 9008-9011Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8018297
Keywords
-
Categories
Funding
- Specialized Research Fund [20060542007]
- National Natural Science Foundation of China [20572020]
- New Century Excellent Talents in University [NCET-06-0711]
Ask authors/readers for more resources
A novel electrophilic ipso-cyclization involving an electrophile-exchange process has been developed. In the presence of CuX (X = I, Br, SCN) and electrophilic fluoride reagents, a variety of N-(p-methoxyaryl)propiolamides and 4-methoxyphenyl 3-phenylpropiolate were cyclized to selectively afford the corresponding spiro[4.5]decenones in moderate to good yields. It is noteworthy that two azaquaternary tricyclic products were synthesized through a two-step pathway involving an electrophilic ipso-cyclization and then an intramolecular Heck reaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available