Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 17, Pages 6857-6859Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8007034
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- CSIR, New Delhi
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Gold(III) chloride is found to be an effective catalyst for the addition of alkynes on activated quinoline/isoquinolines to produce a series of alkynyl-substituted 1,2-dihydroquinolines and isoquinolines in a single-step operation. The easy availability of starting materials, convenient synthetic procedure, operational simplicity, and high regioselectivity makes this strategy very useful for the preparation of enyne derivatives of aza-aromatic compounds.
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