Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 18, Pages 7219-7223Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo801152c
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Funding
- National Institute of General Medical Sciences, Department of Health and Human Services [GM079590, GM081261]
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A general method for the synthesis of bis-substituted 1,2,4-oxadiazoles from readily available aryinitriles and activated carbonyls in a single continuous microreactor sequence is described. The synthesis incorporates three sequential microreactors to produce 1,2,4-oxadiazoles in similar to 30 min in quantities (40-80 mg) sufficient for full characterization and rapid library supply.
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