Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 21, Pages 8608-8611Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8017654
Keywords
-
Categories
Funding
- Natural Science Foundation of China [20629202]
- Chinese Academy of Sciences
Ask authors/readers for more resources
Reactions of 2-amino-aryl alcohols with beta-ketoesters catalyzed by a catalytic amout of FeCl3 via tandem benzylation-cyclization produce the corresponding 3-quinolinecarboxylic esters in good to high yields. Extending this methodology to propargylation-cyclization, 2-nitrophenyl proparoyl alcohols with beta-ketoesters catalyzed by FeCl3 and SnCl, also produce the 4-alkyne-3-quitiolinecarboxylic esters. The mechanistic details of this benzylation/proparoylation and cyclization cascade process are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available