4.7 Article

Synthesis of 2-cyclohexenone derivatives via gold(I)-catalyzed hydrative cyclization of 1,6-diynes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 19, Pages 7811-7813

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo800974x

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Funding

  1. Natural Science Foundation of China [20572094, 20672099]
  2. Government of Zhejiang Province of China [2007R10022]

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The gold(I) complex (MeAuPPh3) was found to be a highly effective catalyst for the hydrative cyclization of 1,6-diynes to form the corresponding 3-methyl hex-2-enone derivatives with good to excellent yield. The proposed mechanism is described.

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