4.7 Article

Regioselective palladium cross-coupling of 2,4-dihalooxazoles: Convergent synthesis of trisoxazoles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 8, Pages 3303-3306

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo800121y

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A regioselective Suzuki-Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles in high yield and in a minimum number of steps.

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