Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 11, Pages 4299-4301Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo800267q
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Trifluoroacetic acid (TFA) is an effective promoter of the bimolecular Ritter-like oxidative amidation of 4-substituted phenols induced by PhI(OAc)(2) in MeCN. This suppresses the need for fluoroalcohol cosolvents, increases the yields, and facilitates isolation/purification procedures.
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