Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 3, Pages 1121-1123Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo7021372
Keywords
-
Categories
Ask authors/readers for more resources
[GRAPHICS] The preparation of the selective VEGF-R2 kinase inhibitor 10 (JNJ-17029259) is described in which the key precursor, 4-(5-isoxazolyl)benzonitrile, undergoes clean transformation to the corresponding cumylamine derivative with CeCL3-MeLi in THF. This high-yielding cerium mediated transformation is robust, reproducible, and readily scalable based on a requirement for the anhydrous CeCl3 to be milled and subjected to ultrasound treatment prior to addition of methyllithium.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available