4.7 Article

Biosynthesis of spiro-Mamakone A, a Structurally Unprecedented Fungal Metabolite

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 21, Pages 8635-8638

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo801564c

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Biosynthetic studies on spiro-mamakone A (1), a potently cytotoxic and antimicrobial Compound from an endophytic fungus isolated from the New Zealand native tree Knightia excelsa (rewarewa), confirm the polyketide origins of this unique compound belonging to the spirobisnaphthalene class of compounds. The biosynthesis proceeds via an unprecedented symmetric enedione with the two halves of the Molecule being formed from two separate pentaketide units connected by oxidative coupling

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