Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 11, Pages 3985-3995Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo800094q
Keywords
-
Categories
Ask authors/readers for more resources
Asymmetric reduction of ketimines 1a-e with trichlorosilane can be catalyzed by the N-methylvaline-derived Lewis basic formamide anchored to a polymeric support (5a and 5b) with good enantioselectivity (<= 82% ee) and low catalyst loading (typically 15 mol %) at room temperature. This protocol represents a considerable simplification of the isolation procedure and is particularly suitable for a parallel synthesis of chiral amines 2a-e. The polymer-supported catalysts retain full activity after a multiple use.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available