Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 23, Pages 9426-9434Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo8020743
Keywords
-
Categories
Funding
- National Science Foundation [CHE-0243410]
- Molecular Graphics and computation Facility, College of Chemistry, UC Berkeley
- NSF [CHE-0233882]
Ask authors/readers for more resources
Various disparate experimental results are explained by the hypothesis that reactions of anionic nucleophiles with allylic halides are generally S(N)2. The S(N)2' reactions that do Occur proceed generally with anti stereochemistry. Reactions with ion pair nucleophiles Occur preferentially LIS S(N)2' reactions with syn stereochemistry. This hypothesis is consistent with a variety Of computations at the HF, B3LYP, mPWIPW91 and MP2 levels with the 6-31+G(d) basis set of reactions of Li and Na fluoride and chloride with allyl halides and 4-halo-2-pentenes. Solvation is considered by a combination of coordination of dimethyl ether to the lithium and sodium cations and dielectric solvation with a polarized continuum model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available