Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 2, Pages 538-549Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo701987r
Keywords
-
Categories
Ask authors/readers for more resources
[GRAPHICS] A highly efficient method of indole synthesis using gem-dihalovinylaniline substrates and an organoboron reagent was developed via a Pd-catalyzed tandem intramolecular amination and an intermolecular Suzuki coupling. Aryl, alkenyl, and alkyl boron reagents are all successfully employed, making for a versatile modular approach. The reaction tolerates a variety of substitution patterns on the aniline leading to indoles with group at C-2-C-7. The orthogonal approach of the sequential copper- and palladium-mediated synthesis of 1,2-diarylindoles exploited the wide availability of diverse organoboron reagents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available