Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 18, Pages 7102-7107Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo801279r
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Funding
- National Institutes of Health [GM46059]
- MIT-Singapore Alliance
- American Chemical Society Organic Division
- Novartis
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A method for the Pd-catalyzed carbonylation of aryl bromides has been developed using Xantphos as the ligand. This method is effective for the direct synthesis of Weinreb amides, 1 degrees and 2 degrees benzamides, and methyl esters from the corresponding aryl bromides at atmospheric pressure. In addition, a putative catalytic intermediate, (Xanphos)Pd(Br)benzoyl, was prepared and an X-ray crystal structure was obtained revealing an unusual cis-coordination mode of Xantphos in this palladium-acyl complex.
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