Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 22, Pages 8731-8744Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo801123q
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Funding
- DST, New Delhi [SR/S1/OC-01/2007]
- CSIR, New Delhi
- UGC
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Sugar amino acid based 24-membered macrocycliC C-2-symmetric cationic peptides were designed and synthesized. The cationic group was introduced in the sugar amino acids. The conformation of these cyclic compounds was ascertained through NMR techniques, which proved they were amphipathic in nature. All the compounds were bacteriolytic, showed good activity against the Gr(+v)e and Gr(-ve) bacteria, and exhibited low hemolytic activity.
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