Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 73, Issue 17, Pages 6928-6931Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo801181d
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Funding
- National Institutes of Health [GM 08216]
- INBRE [NC P20 RR-016470]
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A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A variety of mexiletine analogues were prepared in good yield with excellent enantioselectivities (91-97% ee) from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel beta-amino ethers containing thiophenyl and pyridyl fragments.
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