Journal
JOURNAL OF ORAL PATHOLOGY & MEDICINE
Volume 41, Issue 5, Pages 394-399Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0714.2011.01110.x
Keywords
biomarker; immunohistochemistry; matrix metalloproteinase; oral tongue cancer; prognosis
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Funding
- Suomalais-Norjalainen Laaketieteen Saatio
- Korvatautien tutkimussaatio
- Finnish Dental Society Apollonia
- Academy of Finland
- Helsinki University Central Hospital
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BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease progression are not fully known. We aimed at finding new predictive markers for diagnosis and disease monitoring. METHODS: Seventy-three consecutive T1N0M0 and T2N0M0 OTSCC patients treated at Helsinki University Central Hospital, Helsinki, Finland, in 1992-2002 were included. Tissue array blocks were prepared from primary tumors and immunostained. Immunoexpression of matrix metalloproteinase (MMP)-2, -8, -9, and -13 was compared with patient characteristics and outcome. RESULTS: Nuclear expression of MMP-13, but not cytoplasmic expression of MMP-2, -8, and -9, was associated with invasion depth (P = 0.017) and tumor size (P = 0.008). Furthermore, high nuclear MMP-13 expression was predictive of poor outcome (P = 0.042). CONCLUSION: Our results suggest that especially MMP-13 may be regarded as a prognostic biomarker in OTSCC. J Oral Pathol Med (2012) 41: 394-399
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