Journal
JOURNAL OF ORAL PATHOLOGY & MEDICINE
Volume 40, Issue 6, Pages 451-455Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0714.2010.00964.x
Keywords
immunohistochemistry; osteopontin; prognostic factors; salivary gland carcinomas
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Funding
- foundation of Oda Pedersen
- Danish Head and Neck Cancer Group
- foundation of ENT doctor Hans Skouby and wife Emma Skouby
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BACKGROUND: In several cancer types, osteopontin (OPN) expression has been correlated with tumor progression and prognosis. Two earlier studies have examined OPN expression in salivary gland carcinomas with contradictory results. METHODS: One hundred and seventy-five patients with a primary salivary gland carcinoma diagnosed from January 1, 1990 to December 31, 2005 were identified in the local pathology register, Odense University Hospital. Criteria as documented by Allred et al. were used to assess OPN immunostaining that was performed on surgical specimens. RESULTS: Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known prognostic factors in salivary gland carcinomas was insignificant. CONCLUSIONS: Salivary gland carcinomas express OPN. The expression does not correlate with known prognostic factors. J Oral Pathol Med (2011) 40: 451-455
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