Journal
JOURNAL OF OLEO SCIENCE
Volume 62, Issue 3, Pages 181-186Publisher
JAPAN OIL CHEMISTS SOC
DOI: 10.5650/jos.62.181
Keywords
adonirubin; adonixanthin; anti-oxidative activity; anti-tumor-promoting activity; anti-carcinogenic activity
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Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from beta-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and quenching of singlet oxygen as those of astaxanthin. Furthermore, adonirubin and adonixanthin exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene and promoted by 12-O-tetradecanoylphorbol-13-acetate.
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