Journal
JOURNAL OF OLEO SCIENCE
Volume 58, Issue 8, Pages 415-419Publisher
JAPAN OIL CHEMISTS SOC
DOI: 10.5650/jos.58.415
Keywords
imaging mass spectrometry; imaging of lipids; MALDI-QIT-TOF; medaka; metabolome
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Funding
- Young Scientists B [20790419]
- Young Scientists S [20670004]
- Grants-in-Aid for Scientific Research [20790419] Funding Source: KAKEN
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Visualization of endogenous molecules in small experimental animals is very important in order to investigate the localization of specific molecules. Conventional imaging techniques are not suitable for simultaneous visualization of endogenous molecules. We recently developed a new imaging method-imaging mass spectrometry (IMS) using matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF). In this study, we applied IMS using MALDI-QIT-TOF to visualize the metabolites in medaka (Oryzias latipes) sections and determined the spatial distribution of metabolites including lipids.
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