Journal
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
Volume 56, Issue 8, Pages 834-839Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0000000000000183
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Funding
- Passport Foundation
- Science Innovation Fund
- Natural Resources Defense Council (NRDC), Science Center
- National Center for Advancing Translational Sciences (NCATS)
- Northern California Educational Resource Center-Occupational Safety and Health Education Residency Training (Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health) [UL1 TR000004]
- National Institutes of Health, through University of California, San Francisco Clinical and Translational Science Institute [T-42- OH008429]
- Occupational & Environmental Medicine Residency Training Enhancement Award (Health Resources and Services Administration) [D33HP19037]
- Natural Resources Defense Council
- Occupational Physicians Scholarship Fund
- National Institute of Occupational Safety and Health
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Objective: We sought to quantify absorption of triclosan, a potential endocrine disruptor, in health care workers with occupational exposure to soap containing this chemical. Methods: A cross-sectional convenience sample of two groups of 38 health care workers at separate inpatient medical centers: hospital 1 uses 0.3% triclosan soap in all patient care areas; hospital 2 does not use triclosan-containing products. Additional exposure to triclosan-containing personal care products was assessed through a structured questionnaire. Urine triclosan was quantified and the occupational contribution estimated through regression modeling. Results: Occupational exposure accounted for an incremental triclosan burden of 206 ng/mL (P = 0.02), while triclosan-containing toothpaste use was associated with 146 ng/mL higher levels (P < 0.001). Conclusions: Use of triclosan-containing antibacterial soaps in health care settings represents a substantial and potentially biologically relevant source of occupational triclosan exposure.
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