Journal
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
Volume 53, Issue 3, Pages 282-289Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0b013e31820c2bff
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Funding
- Berufsgenossenschaft der keramischen und Glas-Industrie (BGGK, now VBG)
- Steinbruchs-Berufsgenossenschaft (StBG, now BG RCI)
- EUROSIL, the European Association of Industrial Silica Producers
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Objective: To quantify silicosis and lung cancer risks among porcelain workers occupationally exposed to respirable crystalline silica. Methods: We reread historical radiographs to identify silicosis and estimated exposure on the basis of detailed work history and about 8000 industrial hygiene measurements. Cox proportional hazards models estimated risks by cumulative and average exposure. Results: Adjusted silicosis hazards ratios were 5.3 (95% confidence interval [CI], 1.6 to 17.3); 7.3 (95% CI, 2.6 to 20.8); and 6.8 (95% CI, 3.0 to 15.3) for cumulative exposures > 4 to 5; > 5 to 6; and > 6 mg/m(3)-years, and 3.3 (95% CI, 0.8 to 14.7), 13.6 (95% CI, 4.2 to 44.4) and 23.2 (95% CI, 8.2 to 65.8) for average exposures > 0.1 to 0.15; > 0.15 to 0.2 and > 0.2 mg/m(3), respectively. Exposure was not associated with any cause of death including lung cancer. Conclusions: Respirable crystalline silica exposure more than 4 mg/m(3)-years (cumulative) or more than 0.15 mg/m(3) (average) were strongly associated with silicosis, but unrelated to lung cancer risks.
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