Journal
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Volume 31, Issue 3, Pages 245-249Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/01443615.2010.546906
Keywords
ICSI; infertility; obesity; polycystic ovary syndrome
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The objective of the study was to compare intracytoplasmic sperm injection (ICSI) outcome and gonadotropin doses between obese women with PCOS and non-obese patients with PCOS. This follow-up study represents ICSI outcomes in obese women with PCOS (BMI >= 30 kg/m(2)) compared with non-obese women with PCOS (BMI < 30 kg/m(2)). Obese (n=18) and non-obese (n=26) women with PCOS underwent long protocol pituitary suppression, ovarian stimulation and ICSI with fresh embryo transfer. Obese patients with PCOS required higher doses of gonadotropin (2994 IU vs 1719 IU; p < 0.001). Miscarriage rate was significantly higher in obese women compared with the non-obese women with PCOS (60% vs 6.7%, p=0.002). Our results are valuable for counselling couples before initiation of assisted reproduction techniques (ART).
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