Journal
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Volume 31, Issue 5, Pages 429-435Publisher
INFORMA HEALTHCARE
DOI: 10.3109/01443615.2011.576282
Keywords
Mesh; pelvic organ prolapse; polydioxanone; polyglactin; sutures
Categories
Funding
- UK NIHR
- Health Services Research Unit, University of Aberdeen
- Chief Scientist Office of the Scottish Government Health Directorates
- Chief Scientist Office [HSRU1] Funding Source: researchfish
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The effects at 2 years of polyglactin (Vicryl) mesh inlay and polydioxanone (PDS) or polyglactin (Vicryl) suture material on prolapse symptoms, urinary, bowel, sexual function and prolapse related Quality-of-Life (QoL) in women undergoing pelvic organ prolapse surgery were evaluated in a randomised controlled trial with a 2 x 2 factorial design of Vicryl mesh (n = 32) or not (n = 34) and PDS (n = 33) or Vicryl suture (n = 33). The response rate at 2 years was 82%. There were no differences in the prolapse symptom scores between the randomised groups. Prolapse-related QoL score (mean difference: 2.05, 95% CI 0.19-3.91) and urinary incontinence score (mean difference: 2.56, 95% CI 0.02-5.11) were significantly lower (better) in women who had Vicryl compared with PDS sutures. The apparent superiority of the prolapse-related QoL and urinary incontinence scores in women using Vicryl suture material (vs PDS) needs to be confirmed in a larger trial.
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