Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 23, Issue 7, Pages 817-821Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2011.04.005
Keywords
Food intake; Inflammation; Public health; Pulmonary disease; chronic obstructive
Funding
- Spanish Society of Pneumology and Thoracic Surgery [SEPAR 2006/149]
- Instituto de Salud Carlos III [FI05/01022]
- Ministry of Health, Spain
- Fondo de Investigacion Sanitaria [FIS PI020541, PI052486, PI052302]
- Ministry of Health, Spain
- Agencia d'Avaluacio de Tecnologia i Recerca Mediques [AATRM 035/20/02]
- Catalonia Government: Spanish Society of Pneumology and Thoracic Surgery [SEPAR 2002/137]
- Catalan Foundation of Pneumology
- Red RESPIRA [RTIC C03/11]
- Red RCESP [RTIC C03/09]
- Fundacio La Marato de TV3 [041110]
- DURSI [20055GR00392]
- Novartis Farmaceutica, Spain
- Institut de Salud Carlos III
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Dietary intake of polyunsaturated fatty acids, including omega-3 and omega-6, could modulate chronic obstructive pulmonary disease (COPD) persistent inflammation. We aimed to assess the relationship between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD. A total of 250 clinically stable COPD patients were included. Dietary data of the last 2 years were assessed using a validated food frequency questionnaire (122 items), which provided levels of three omega-3 fatty acids: docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid (ALA); and two omega-6 fatty acids: linoleic acid and arachidonic acid (AA). Inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNF alpha)] were measured in serum. Fatty acids and inflammatory markers were dichotomised according to their median values, and their association was assessed using multivariate logistic regression. Higher intake of ALA (an anti-inflammatory omega-3 fatty acid) was associated with lower TNFa concentrations [adjusted odds ratio (OR)=0.46; P=.049]. Higher AA intake (a proinflammatory omega-6 fatty acid) was related to higher IL-6 (OR=1.96; P=.034) and CRP (OR=1.95; P=.039) concentrations. Therefore, this study provides the first evidence of an association between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD patients. (C) 2012 Elsevier Inc. All rights reserved.
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