Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 22, Issue 10, Pages 929-936Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2010.07.014
Keywords
Reactive oxygen species; Luteolin; Neuroprotectant; Ischemia; Reperfusion; Oxidant-antioxidant balance
Funding
- Shanghai government [05DZ19339]
- Chinese Academy of Science
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Oxidative stress-induced neuronal cell death has been implicated in neurodegenerative diseases; one such disease is ischemic stroke. Using reactive oxygen species (ROS)-insulted primary neurons, we screened neuroprotectants with clinical potential and then, using ischemia/reperfusion (I/R) model, investigated the anti-ischemic potential of candidate neuroprotectants. Here, we showed that luteolin, isolated from the ripe fruit of Perilla frutescens (L) Britt, exhibited a neuroprotective action upon the in vitro platform, thus serving as candidate for in vivo pharmacological evaluation. Liposome-encapsulated luteolin produced dramatic preventing effects on I/R-induced behavioral and histological injuries after a 13-day post-ischemic treatment. Furthermore, this phytochemical not only lowered the increased level of mitochondria' ROS but also substantially up-regulated the decreased activity of catalase and glutathione in I/R rat brains. Collectively, luteolin as a neuroprotectant acts by anti-ischemic activity likely through a rebalancing of pro-oxidant/antioxidant status. Its multitarget mechanisms implicate potential effectiveness for clinically treating ischemia stroke. (C) 2011 Elsevier Inc. All rights reserved.
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