Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 21, Issue 9, Pages 781-792Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2009.12.004
Keywords
Omega 3 polyunsaturated fatty acids; Cardiovascular disease; Atherosclerosis
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Typical omega 3 polyunsaturated fatty acids (n-3 PUFAs) are docosahexaenoic acid and eicosapentaenoic acid in the form of fish oils and a linolenic acid from flaxseed oil. Epidemiological studies suggested the benefits of n-3 PUFA on cardiovascular health Intervention studies confirmed that the consumption of n-3 PUFA provided benefits for primary and secondary prevention of cardiovascular disease. Evidence from cellular and molecular research studies indicates that the cardioprotective effects of n-3 PUFA result from a synergism between multiple, intricate mechanisms that involve antiinflammation, proresolving lipid mediators, modulation of cardiac ion channels, reduction of triglycerides, influence on membrane microdomains and downstream cell signaling pathways and antithrombotic and antiarrhythmic effects n-3 PUFAs inhibit inflammatory signaling pathways (nuclear factor-kappa B activity) and down-regulate fatty acid (FA) synthesis gene expression (sterol regulatory element binding protein-1c) and up-regulate gene expression involved in FA oxidation (peroxisome proliferator-activated receptor alpha) This review examines the various mechanisms by which n-3 PUFA exert beneficial effects against CVD. Published by Elsevier Inc
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