Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 20, Issue 1, Pages 1-10Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2008.05.016
Keywords
n-3 PUFA; Alzheimer's Disease; DHA; Fish oil; Mouse models
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- J.P. Bickel Foundation
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Dementia such as Alzheimer's disease (AD) is a growing health problem in aging populations in many countries around the world. Currently, there is no cure for AD; consequently, alternative therapies are urgently needed. Recent studies suggest that nutritional intervention may have therapeutic benefits for AD. Specifically, an increased intake of n-3 polyunsaturated fatty acids (PUFA) from fish and marine oils may lower AD risk. This review will summarize the current body of knowledge regarding the association between n-3 PUFA and AD, including human studies and experimental models, and potential mechanisms of action. (C) 2009 Elsevier Inc. All rights reserved.
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