Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women

This study assessed the effects of combined chromium picolinate (CP) and conjugated linoleic acid (CLA) supplementation on energy restriction and exercise-induced changes in body composition, glucose metabolism, lipid lipoprotein profile and blood pressure in overweight, premenopausal women. For 12 weeks, 35 women [age 36 +/- 1 years (mean +/- S.E.M.); BMI 28.0 +/- 0.5 kg/m(2)] were counseled to consume a 2092 kJ/day (500 kcal/day) energy deficit diet and performed 30 min of moderate-intensity walking or jogging 5 days/week. The women were randomly assigned to ingest either CP-CLA [400 mu g chromium (Cr), 1.8 g CLA in 2.4 g tonalin oil, n = 19] or placebo (< 0.1 mu g Cr, 2.4 g canola oil, n = 16). Compared to baseline, urinary Cr excretion increased 22-fold, plasma CLA isomer 18:2 (c9,t11) content increased 79% and plasma CLA isomer 18:2 (t10,c12) became detectable in CP-CLA and were unchanged in Placebo. Over time, body weight decreased 3.5 +/- 0.5% (CP-CLA -2.6 +/- 0.5; placebo -2.5 +/- 0.5 kg) and fat mass decreased 8.9 +/- 1.3% (CP-CLA -2.7 +/- 0.5, placebo -2.4 +/- 0.5 kg), with no differences in responses between groups. Fasting blood hemoglobin A(1c), plasma glucose and insulin, a homeostatic assessment of insulin resistance, serum total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol, triacylglycerol (TG), CHOL/HDL ratio, TG/HDL ratio and sitting systolic and diastolic blood pressures were not changed over time or influenced by CP-CLA. The use of a combined CP and CLA supplement for 3 months does not affect diet- and exercise-induced changes in weight and body composition or improve indexes of metabolic and cardiovascular health in young overweight women. (c) 2008 Elsevier Inc. All rights reserved.