Journal
JOURNAL OF NUTRITION HEALTH & AGING
Volume 18, Issue 4, Pages 441-448Publisher
SPRINGER FRANCE
DOI: 10.1007/s12603-014-0026-2
Keywords
Cell; tendon; aging; tendinopathy; treatment
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Funding
- National Natural Science Foundation of China [81230040]
- China Scholarship Council (CSC)
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Tendons transfer tensile loads from muscle to bone, which enable joint motions and stabilize joints. Tendons sustain large mechanical loads in vivo and as a result, tendons were frequently injured. Aging has been confirmed as a predisposing factor of tendinopathy and bad recovery quality following tendon repair. Current treatment methods are generally not effective and involve either symptomatic relief with non-steroidal antiinflammatory drugs and physical therapy or surgery when conservative treatments failed. The limitation in treatment options is due to our incomplete knowledge of age-related tendinopathy. Studies over the past decades have uncovered a number of important mechanical and cellular changes of aging tendon. However, the basis of aging as a major risk factor for tendon injury and impaired tendon healing remained poorly understood. The objectives of this review are to provide an overview of the current knowledge about the aging-associated changes of structure, mechanical properties and treatment in tendon and highlight causes and therapies for age-related tendinopathy.
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