Journal
JOURNAL OF NUTRITION
Volume 142, Issue 7, Pages 1286-1290Publisher
OXFORD UNIV PRESS
DOI: 10.3945/jn.111.156166
Keywords
-
Categories
Funding
- Biotechnology and Biological Sciences Research Council
- GlaxoSmithKline [RHS00976]
Ask authors/readers for more resources
Uncertainty remains regarding the efficacy of low intakes of ergocalciferol (vitamin D2 or D2) and cholecalciferol (vitamin D3 or D3) provided in food to increase serum 25-hydroxy-vitamin D (25-OH-D) metabolite concentrations when UV-B exposure is low. We recruited 40 healthy men and women into a double-blind, parallel design, randomized controlled trial. Participants received placebo or 1 of 4 experimental treatments (D2 or D3 at 5 or 10 mu g/d) supplied as a malted milk drink for 4 wk during a period of minimal UV-B exposure in the UK. The primary outcome was a change in serum 25-OH-D2 and 25-OH-D3 concentrations measured by ultra-performance liquid chromatography tandem MS. The secondary outcomes were changes in concentrations of plasma parathyroid hormone and serum calcium (Ca2+). Baseline concentrations (geometric mean +/- SD) of 25-OH-D2, 25-OH-03, and total 25-OH-D were 3 +/- 4, 32 +/- 22, and 37 +/- 22 nmol/L, respectively. Both D2- and D3-fortified drinks resulted in dose-dependent increases (P < 0.001) in their respective 25-OH metabolites that did not significantly differ in size. Increments from baseline compared with the placebo group following 5 and 10 mu g/d of D2 were (mean SEM) 9.4 +/- 2.5 and 17.8 +/- 2.4 nmo/L for 25-OH-D2 and following 5 and 10 mu g/d of D3 were 15.1 +/- 4.7 and 22.9 +/- 4.6 nmol/L for 25-OH-D3, respectively. There was no difference between D2 and D3 groups in the incremental AUC of their respective metabolites. These findings suggest that D2 and D3 are equipotent in increasing 25-OH-D in healthy men and women with negligible UV-B exposure. J. Nutr. 142: 1286-1290, 2012.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available