Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 52, Issue 3, Pages 401-404Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.110.081281
Keywords
metabolic activities in the thalamus; PET/MRI; fusion imaging
Funding
- Ministry of Education, Science and Technology, South Korea [2008-04159, R332009000101190]
- National Research Foundation of Korea [2008-04159, 2008-2004159] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The anatomy of the thalamus and its connectivity with surrounding areas are known. Localized metabolic activities at the thalamic substructural level have not been measured in vivo in human brains because of limited resolution and contrast. Methods: The energy metabolism and fine anatomic structures of the thalamus were measured simultaneously in 5 healthy subjects using a PET/MRI fusion imaging system. Measured metabolism in individual thalamic nuclei was quantified by corresponding PET/MRI images. Results: Substructures of the thalamus were clearly distinguished in 7.0-T MRI images, and the corresponding metabolic activities measured by PET were integrated by the PET/MRI system. The medial dorsal thalamic nucleus consistently showed the highest glucose uptake among the thalamic nuclei. Conclusion: These results demonstrate that substructure-specific metabolic activities in the thalamus can be measured with a PET/MRI system consisting of an ultra-high-resolution PET component and an ultra-high-field MRI component.
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