Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 52, Issue 4, Pages 547-550Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.110.083733
Keywords
pituitary gland; focal uptake; incidentaloma; F-18-FDG; PET/CT
Funding
- Samsung Biomedical Research Institute, Republic of Korea [C-B0-320-1]
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The purpose of this study was to identify the incidence and clinical significance of incidental pituitary uptake on whole-body F-18-FDG PET/CT. Methods: We evaluated 13,145 consecutive subjects who underwent F-18-FDG PET/CT. The final diagnosis of pathologic or physiologic uptake was based on brain MRI and follow-up PET scanning. Receiver-operating-characteristic curve analysis was performed to determine an optimal cutoff for detecting pathologic uptake. Results: We found that 107 (0.8%) subjects showed incidental pituitary uptake. In 29 of 71 subjects with the final diagnosis, the pituitary uptake was pathologic: macroadenomas (n = 21), microadenomas (n = 5), and malignancy (n = 3). When a maximum standardized uptake value of 4.1 was used as an optimal criterion for detecting pathologic uptake, the diagnostic sensitivity, specificity, and accuracy were 96.6%, 88.1%, and 91.5%, respectively. Conclusion: Although incidental pituitary uptake is an unusual finding, the degree of F-18-FDG accumulation is helpful in identifying pathologic pituitary lesions that warrant further diagnostic evaluation.
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