Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 52, Issue 1, Pages 1-4Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.110.076018
Keywords
folic acid; folate receptor; SPECT; PET; cancer
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The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates useful for SPECT and PET of cancer diseases. The potential applicability of folate radiopharmaceuticals for FR-targeted radionuclide therapy is also discussed.
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