Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 51, Issue 3, Pages 413-417Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.109.069732
Keywords
myocardial infarction; stem cell therapy; cell labeling; single photon emission computed tomography
Funding
- Heart and Stroke Foundation of Ontario
- Canadian Institutes for Health Research
- Ontario Ministry of Research and Innovation
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Neither intravenous nor intracoronary routes provide targeted stem cell delivery to recently infarcted myocardium in sufficient quantities. Direct routes appear preferable. However, most prior studies have used epicardial injections, which are not practical for routine clinical use. The objective of this study was to compare cell retention and clearance kinetics between a subepicardial and a subendocardial technique. Methods: We evaluated 7 dogs with each technique, using In-111-tropolone-labeled endothelial progenitor cells and serial SPECT/CT for 15 d after injection. Results: In vivo indium imaging demonstrated comparable degrees of retention: 57% +/- 15% for the subepicardial injections and 54% +/- 26% for the subendocardial injections. Clearance half-lives were also similar at 69 +/- 26 and 60 +/- 21 h, respectively. Conclusion: This study demonstrates that subendocardial injections, clinically more practical, show clearance kinetics comparable to those of subepicardial injections and will facilitate the ultimate clinical use of this treatment modality.
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