Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 49, Issue 7, Pages 1177-1182Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.108.051326
Keywords
Cu-ATSM; hypoxia; Cu-60; Cu-64; cervical cancer
Funding
- NCI NIH HHS [R21 CA081525, R24 CA086307] Funding Source: Medline
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Tumor uptake of copper(II)-diacetyl-bis(N-4-methylthiosemicarbazone) (copper-ATSM), a hypoxia-targeting radiopharmaceutical, assessed by PET has been found to correlate with prognosis in several human cancers. Wide clinical utility of this tracer will require its labeling with a copper radionuclide having a longer half-life than the Cu-60 used in studies to date. The purpose of this work was to obtain the requisite preclinical data for copper-ATSM to file an investigational new drug application, followed by a crossover comparison of PET image quality and tumor uptake with Cu-60-ATSM and Cu-64-ATSM in women with cancer of the uterine cervix. Methods: The preclinical toxicology and pharmacology of a copper-ATSM formulation was examined using standard in vitro and in vivo assays, as well as 14-d toxicity studies in both rats and rabbits. For the clinical test-retest imaging study, 10 patients with cervical carcinoma underwent PET on separate days with Cu-60-ATSM and Cu-64-ATSM. Image quality was assessed qualitatively, and the tumor-to-muscle activity ratio was measured for each tracer. Results: The toxicology and pharmacology data demonstrated that the formulation has an appropriate margin of safety for clinical use. In the patient study, we found that the image quality with Cu-64-ATSM was better than that with Cu-60-ATSM because of lower noise. In addition, we found that the pattern and magnitude of tumor uptake of Cu-60-ATSM and Cu-64-ATSM on studies separated by 1-9 d were similar. Conclusion: Cu-64-ATSM appears to be a safe radiopharmaceutical that can be used to obtain high-quality images of tumor hypoxia in human cancers.
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