Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 17, Issue 45, Pages 30292-30299Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cp05202e
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Funding
- Bio & Medical Technology Development Program of the NRF - Korean government, MSIP [2015M3A9D7031015]
- Global Ph.D. Fellowship Program of the National Research Foundation of Korea - Ministry of Education [2013H1A2A1032685]
- Brain Korea 21 Plus Project
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Despite the critical functions of divalent metal ions (M2+ s) in association with duplex DNA, fundamental and general interactions of M2+ s with spherical nucleic acids (SNAs) composed of single-stranded DNA have rarely been investigated. We have explored that the coordinative nature of the M2+-SNA binding mediates the temperature-and base composition-dependent reversible assemblies of SNAs even without the need of complementary counterparts for duplex-interconnection, additional monovalent metal ions for charge screening, or pre-designed sequences for any non-Watson-Crick base-pairing, all of which are essential for the conventional assembly of SNAs. Cu2+ has been identified to maximize the reversible assembly properties in relation to this M2+-mediated DNA bond, and has been further qualitatively and quantitatively investigated in detail as a model system.
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