Journal
JOURNAL OF NON-CRYSTALLINE SOLIDS
Volume 358, Issue 12-13, Pages 1438-1442Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jnoncrysol.2012.03.014
Keywords
Apatite; Bioactive glass; Biomedical applications; Fluorapatite; Fluoride
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Fluorapatite glass-ceramics are osteoconductive. and glass-ceramics containing fluorapatite crystals in a bioactive silicate glass matrix can combine the benefits of fluorapatite with the bone-regenerative properties of bioactive glasses. High phosphate content (around 6 mol% P2O5) bioactive glasses (SiO2-P2O5-CaO-Na2O-CaF2) were prepared by a melt-quench route. Structural investigation using density measurements and calculations confirmed the presence of phosphorus as orthophosphate. Upon heat treatment, the glasses crystallised to mixed sodium calcium fluoride orthophosphates (sodium-containing compositions) and fluorapatite (sodium-free composition). Fluoride suppressed spontaneous crystallisation, allowing formation of glass-ceramics by controlled crystallisation. A notable feature is that silicate network polymerisation and network connectivity did not change during crystallisation, resulting in orthophosphate and fluorapatite crystals embedded within a bioactive glass matrix. By keeping the phosphate content high and the sodium content low, fluorapatite glass-ceramics can be obtained, while not affecting the structure of the bioactive silicate glass phase. (C) 2012 Elsevier B.V. All rights reserved.
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