Journal
JOURNAL OF NEUROVIROLOGY
Volume 20, Issue 2, Pages 122-136Publisher
SPRINGER
DOI: 10.1007/s13365-013-0188-4
Keywords
Virus-induced neuroinflammation; Demyelination; Axonal loss; Multiple sclerosis
Categories
Funding
- Department of Biotechnology (DBT)
- Council for Scientific and Industrial Research (CSIR)
- IISER-K, India
- National Multiple Sclerosis Society, USA
- M.E. Groff Surgical Medical Research and Education Charitable Trust
- Lindback Foundation Career Enhancement Award, USA
Ask authors/readers for more resources
Microglia, the major resident immune cells in the central nervous system (CNS) are considered as the key cellular mediators of neuroinflammatory processes. In the past few years, microglial research has become a main focus in cellular neuroimmunology and neuroinflammation. Chronic/remitting neurological disease such as multiple sclerosis (MS) has long been considered an inflammatory autoimmune disease with the infiltration of peripheral myelin-specific T cells into the CNS. With the rapid advancement in the field of microglia and astrocytic neurobiology, the term neuroinflammation progressively started to denote chronic CNS cell-specific inflammation in MS. The direct glial responses in MS are different from conventional peripheral immune responses. This review attempts to summarize current findings of neuroinflammatory responses within the CNS by direct infection of neural cells by mouse hepatitis virus (MHV) and the mechanisms by which glial cell responses ultimately contribute to the neuropathology on demyelination. Microglia can be persistently infected by MHV. Microglial activation and phagocytosis are recognized to be critically important in the pathogenesis of demyelination. Emerging evidence for the pathogenic role of microglia and the activation of inflammatory pathways in these cells in MHV infection supports the concept that microglia induced neuroinflammation is an amplifier of virus-induced neuropathology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available