Journal
JOURNAL OF NEUROVIROLOGY
Volume 18, Issue 4, Pages 247-255Publisher
SPRINGER
DOI: 10.1007/s13365-011-0073-y
Keywords
HIV; Aging; Immune senescence; Chronic inflammation; Cardiovascular; Frailty
Categories
Ask authors/readers for more resources
HIV-infected patients are living longer as a result of potent antiretroviral therapy. Immuno-inflammatory phenomena implicated in the normal aging process, including immune senescence, depreciation of the adaptive immune system, and heightened systemic inflammation are also pathophysiologic sequelae of HIV infection, suggesting HIV infection can potentiate the biological mechanisms of aging. Aging HIV-infected patients manifest many comorbidities at earlier ages, and sometimes with more aggressive phenotypes compared to seronegative counterparts. In this review, we describe relevant biologic changes shared by normal aging and HIV infection and explore the growing spectrum of clinical manifestations associated with the accelerated aging phenotype in HIV-infected individuals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available