Journal
JOURNAL OF NEUROVIROLOGY
Volume 17, Issue 6, Pages 552-558Publisher
SPRINGER
DOI: 10.1007/s13365-011-0071-0
Keywords
Herpes simplex virus type 1; Latent infections; Innervating sensory neurons; Latency associated transcript; Maintenance of latency; Reactivation; Mouse model
Categories
Funding
- National Eye Institute [R01 EY 013168]
- National Institute of Allergy and Infectious Diseases [RO1 AI 32121]
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Herpes simplex virus (HSV) establishes latent infections in sensory neurons from which it can periodically reactivate and cause recurrent disease and transmission to new hosts. Little is known about the virally encoded mechanisms that influence the maintenance of HSV latent infectious and modulate the frequency of virus reactivation from the latent state. Here, we report that the latency associated transcript locus of HSV-1 is required for long-term maintenance of reactivation competent latent infections.
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