Journal
JOURNAL OF NEUROVIROLOGY
Volume 14, Issue 1, Pages 73-77Publisher
SPRINGER
DOI: 10.1080/13550280701801107
Keywords
biomarker; interferon therapy; MSRV/HERV-W endogenous retro-virus; multiple sclerosis
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The authors performed a longitudinal evaluation of multiple sclerosis (MS) patients, during 1 year of therapy with interferon-beta (IFN-beta), by clinical examination and detection of presence in the blood and viral load of MS-associated retrovirus (MSRV), by MSRVenv-specific, fully quantitative, real time reverse transcriptase-polymerase chain reaction (RT-PCR). MSRV load in the blood was directly related to MS duration and fell below detection limits within 3 months of IFN therapy; one patient had strong progression, accompanied by total MSRV rescue. These findings suggest that evaluation of plasmatic MSRV could be considered the first prognostic marker for the individual patient, to monitor disease progression and therapy outcome.
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