Journal
JOURNAL OF NEUROTRAUMA
Volume 27, Issue 5, Pages 789-801Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2008.0809
Keywords
collagen; contusion; laminin; Matrigel; matrix; methylcellulose
Funding
- NIH NINDS [R01NS056281]
- Miami Project
- Buoniconti Fund
- Fa Bene, Schumann, Craig H. Neilsen, and Bryon Riesch Paralysis Foundations
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Trauma to the spinal cord produces endogenously irreversible tissue and functional loss, requiring the application of therapeutic approaches to achieve meaningful restoration. Cellular strategies, in particular Schwann-cell implantation, have shown promise in overcoming many of the obstacles facing successful repair of the injured spinal cord. Here, we show that the implantation of Schwann cells as cell suspensions with in-situ gelling laminin: collagen matrices after spinal-cord contusion significantly enhances long-term cell survival but not proliferation, as well as improves graft vascularization and the degree of axonal in-growth over the standard implantation vehicle, minimal media. The use of a matrix to suspend cells prior to implantation should be an important consideration for achieving improved survival and effectiveness of cellular therapies for future clinical application.
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