Journal
JOURNAL OF NEUROTRAUMA
Volume 27, Issue 8, Pages 1489-1498Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2009.1057
Keywords
neomembrane; neovascularization; rat; subdural hematoma
Funding
- National Natural Science Foundation of China [30772229]
- National 973 Projects of China [2005CB522605]
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Studies on the pathophysiology of subdural hematomas (SDH) have been primarily focused on the acute phase and associated cortical injury, whereas the course of hematoma absorption remains poorly understood. Using a rat model of SDH, we have specifically investigated the correlation between neovascularization of membrane and the rate of hematoma absorption. Using improved surgical techniques, we have reduced surgery-related injury and increased the rate of generating successful SDH to 71.4%. With this model, we demonstrate that hematoma absorption was slow in the first 4 days and accelerated thereafter. The absorption rate and recovery of sensorimotor deficits were closely associated with neovascularization in the neomembrane characterized by the formation of arachnoid granulation-like structures at the interface between the hematoma and encapsulating neomembrane. Our data suggest that neovasculaturization in the neomembrane plays a key role in hematoma absorption and neuronal recovery. Furthermore, measures to enhance neovasculaturization could have therapeutic potentials.
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