Journal
JOURNAL OF NEUROTRAUMA
Volume 26, Issue 10, Pages 1635-1643Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2009.0896
Keywords
cognitive; creatine; glutamate; mild traumatic brain injury; spectroscopy
Funding
- DOE [DE-FG02-99ER62764]
- National Institutes of Health [R24HD050836, R21-NS064464-01A1]
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Single-voxel proton magnetic resonance imaging (H-1-MRS) and proton MR spectroscopic imaging (H-1-MRSI) were used to compare brain metabolite levels in semi-acute mild traumatic brain injury (mTBI) patients (n = 10) and matched healthy controls (n = 9). The H-1-MRS voxel was positioned in the splenium, a region known to be susceptible to axonal injury in TBI, and a single H-1-MRSI slice was positioned above the lateral ventricles. To increase sensitivity to the glutamate (Glu) and the combined glutamate-glutamine (Glx) signal, an inter-pulse echo time shown to emphasize the major Glu signals was used along with an analysis method that reduces partial volume errors by using water as a concentration standard. Our preliminary findings indicate significantly lower levels of gray matter Glx and higher levels of white matter creatine-phosphocreatine (Cr) in mTBI subjects relative to healthy controls. Furthermore, Cr levels were predictive of executive function and emotional distress in the combined groups. These results suggest that perturbations in Cr, a critical component of the brain's energy metabolism, and Glu, the brain's major neurotransmitter, may occur following mTBI. Moreover, the different pattern of results for gray and white matter suggests tissue-specific metabolic responses to mTBI.
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